What is Human tissue transglutaminase?

Tissue transglutaminase (tTG) which exists in human body is a member of the transglutaminase family. As opposed to microbial transglutaminase (mTG) contained in ACTIVA® preparations, tTG is Ca²+ dependent, has higher molecular weight and far higher deamidation activity. Also, sequence homology and three-dimensional structure are different. Thus, characteristics of tTG are different from microbial transglutaminase (mTG), although it also catalyzes the cross-link of side chains of two amino acids, glutamine and lysine, in liquefied proteins.